Nuclear Shell Structure and Chaotic Dynamics in Hexadecapole Deformation

The effect of an axially symmetric hexadecapole term is investigated in a strongly deformed quadrupole potential. While the system is nonintegrable and shows significant chaotic behaviour classically, the quantum mechanical treatment not only produces a general smoothing effect with regard to chaos but even yields a pronounced shell structure at certain hexadecapole strength parameter values for oblate and prolate deformation.Comment: RevTeX + 4 figs. available from the authors, to appear in Phys.Rev.

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs

Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who manifested HSRs clinically, to correlate LTA results with the clinical syndrome, to correlate LTA results with the human leukocyte antigen (HLA) allele B*1502 (HLA-B*1502) positivity in a Han Chinese-Canadian population, and to determine the cytokine network in this population. HSR patients developed fever and cutaneous eruptions in the presence or absence of organ involvement within 8 weeks of exposure to carbamazepine (CBZ), phenytoin (PHY) or lamotrigine (LTG). Control patients received AEDs without presenting HSR. We investigated 10 CBZ-HSR (4 presented with Stevens-Johnson syndrome (SJS)), 24 CBZ-controls, 10 PHY-HSR (4 presented with drug-induced liver injury (DILI)), 24 PHY-controls, 6 LTG-HSR (1 SJS and 1 DILI) and 24 LTG-controls. There were 30 Han Chinese individuals (14 HSR patients and 16 controls) in our cohort. LTA toxicity greater than 12.5%±2.5% was considered positive. Differences among groups were determined by analysis of variance. In addition, we measured cytokine secretion in the patient sera between 1 month and 3 years after the event. All Han Chinese individuals and 30% of Caucasians were genotyped for HLA-B*1502.A perfect correlation (r=0.92) was observed between positive LTA and clinical diagnosis of DILI and SJS/toxic epidermal necrolysis (TEN). HLA-B*1502 positivity in Han Chinese is a predictor of CBZ-HSR and PHY-HSR. HLA-B*1502-negative Han Chinese receiving only CBZ or a combination of CBZ-PHY tolerated the drug(s) clinically, presenting negative CBZ-LTA and PHY-LTA. However, 3 patients presenting negative CBZ-LTA and PHY-LTA, as well as negative HLA-B*1502, showed positive LTG-LTA (38%, 28% and 25%, respectively), implying that they should not be prescribed LTG. Three patients had LTA positive to both PHY and CBZ, and 3 others had LTA positive to both PHY and LTG. Clinically, all six patients presented HSR to both drugs that they tested positive to (cross-reactivity). Patients were grouped based on the clinical presentation of their symptoms as only rash and fever or a triad that characterizes "true" HSR (rash, fever and DILI or SJS/TEN). Levels of pro-inflammatory cytokines were significantly higher in patient sera compared to control sera. More specifically, the highest levels of tumor necrosis factor (TNF)-α was measured in patients presenting "true" HSR, as were the apoptotic markers Fas, caspase 8 activity and M30. We concluded that LTA is sensitive for DILI and SJS/TEN regardless of drug or ethnicity. HSR prediction will prevent AED-induced morbidity. In Han Chinese, HLA-B*1502 positivity is a predictor for CBZ-HSR and PHY-HSR. Its negativity does not predict a negative LTG-HSR. There is cross-reactivity between AEDs. Additionally, T-cell cytokines and chemokines control the pathogenesis of SJS/TEN and DILI, contributing to apoptotic processes in the liver and in the skin

On the continuity of spectra for families of magnetic pseudodifferential operators

For families of magnetic pseudodifferential operators defined by symbols and magnetic fields depending continuously on a real parameter $\epsilon$, we show that the corresponding family of spectra also varies continuously with $\epsilon$.Comment: 22 page

Nonabelian solutions in N=4, D=5 gauged supergravity

We consider static, nonabelian solutions in N=4, D=5 Romans' gauged supergravity model. Numerical arguments are presented for the existence of asymptotically anti-de Sitter configurations in the $N=4^+$ version of the theory, with a dilaton potential presenting a stationary point. Considering the version of the theory with a Liouville dilaton potential, we look for configurations with unusual topology. A new exact solution is presented, and a counterterm method is proposed to compute the mass and action.Comment: 15 pages, 4 figure

Field-induced suppression of the heavy-fermion state in YbRh_2Si_2

We report DC magnetization measurements on YbRh_2Si_2 at temperatures down to 0.04K, magnetic fields B<11.5T and under hydrostatic pressure P<1.3GPa. At ambient pressure a kink at B*=9.9T indicates a new type of field-induced transition from an itinerant to a localized 4f-state. This transition is different from the metamagnetic transition observed in other heavy fermion compounds, as here ferromagnetic rather than antiferromagnetic correlations dominate below B*. Hydrostatic pressure experiments reveal a clear correspondence of B* to the characteristic spin fluctuation temperature determined from specific heat

Computing Probabilistic Bisimilarity Distances for Probabilistic Automata

The probabilistic bisimilarity distance of Deng et al. has been proposed as a robust quantitative generalization of Segala and Lynch's probabilistic bisimilarity for probabilistic automata. In this paper, we present a characterization of the bisimilarity distance as the solution of a simple stochastic game. The characterization gives us an algorithm to compute the distances by applying Condon's simple policy iteration on these games. The correctness of Condon's approach, however, relies on the assumption that the games are stopping. Our games may be non-stopping in general, yet we are able to prove termination for this extended class of games. Already other algorithms have been proposed in the literature to compute these distances, with complexity in $\textbf{UP} \cap \textbf{coUP}$ and \textbf{PPAD}. Despite the theoretical relevance, these algorithms are inefficient in practice. To the best of our knowledge, our algorithm is the first practical solution. The characterization of the probabilistic bisimilarity distance mentioned above crucially uses a dual presentation of the Hausdorff distance due to M\'emoli. As an additional contribution, in this paper we show that M\'emoli's result can be used also to prove that the bisimilarity distance bounds the difference in the maximal (or minimal) probability of two states to satisfying arbitrary $\omega$-regular properties, expressed, eg., as LTL formulas

Estimation of a Noise Level Using Coarse-Grained Entropy of Experimental Time Series of Internal Pressure in a Combustion Engine

We report our results on non-periodic experimental time series of pressure in a single cylinder spark ignition engine. The experiments were performed for different levels of loading. We estimate the noise level in internal pressure calculating the coarse-grained entropy from variations of maximal pressures in successive cycles. The results show that the dynamics of the combustion is a nonlinear multidimensional process mediated by noise. Our results show that so defined level of noise in internal pressure is not monotonous function of loading.Comment: 12 pages, 6 figure

Two-stage Kondo effect in a four-electron artificial atom

An artificial atom with four electrons is driven through a singlet-triplet transition by varying the confining potential. In the triplet, a Kondo peak with a narrow dip at drain-source voltage V_ds=0 is observed. The low energy scale V_ds* characterizing the dip is consistent with predictions for the two-stage Kondo effect. The phenomenon is studied as a function of temperature T and magnetic field B, parallel to the two-dimensional electron gas. The low energy scales T* and B* are extracted from the behavior of the zero-bias conductance and are compared to the low energy scale V_ds* obtained from the differential conductance. Good agreement is found between kT* and |g|muB*, but eV_ds* is larger, perhaps because of nonequilibrium effects.Comment: 7 pages, 7 figures. Added labels on Fig. 3f and one referenc